TUSSILAGONE NO FURTHER A MYSTERY

Chemotherapy was potentiated by E7449 and one agent had major antitumor activity in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell strains, very likely as a result of TNKS inhibition. In step with this risk, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and noticeably